Somatic mutations, acetylator status, and prognosis in colorectal cancer.

doi:10.1136/gut.42.5.669

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Article

Somatic mutations, acetylator status, and prognosis in colorectal cancer.

Gut - 1 May 1998

Hardingham J E, Butler W J, Roder D, Dobrovic A, Dymock R B, Sage R E, Roberts-Thomson I C

Abstract excerpt

BACKGROUND: Somatic mutations in K-ras and TP53 may be associated with both acetylator status and prognosis in colorectal cancer. AIMS: To determine whether cancers with somatic mutations are more frequent in fast acetylators and whether mutations or acetylator status influence prognosis after co...

Topics

Acetylation
Arylamine N-Acetyltransferase
Colorectal Neoplasms
Genes, p53
Genes, ras
Humans
Mutation
Neoplasm Staging
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Prognosis
Proportional Hazards Models
Survival Rate

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