Article
Somatic mutations, acetylator status, and prognosis in colorectal cancer.
Gut - 1 May 1998
Hardingham J E, Butler W J, Roder D, Dobrovic A, Dymock R B, Sage R E, Roberts-Thomson I C
Abstract excerpt
BACKGROUND: Somatic mutations in K-ras and TP53 may be associated with both acetylator status and prognosis in colorectal cancer. AIMS: To determine whether cancers with somatic mutations are more frequent in fast acetylators and whether mutations or acetylator status influence prognosis after colorectal surgery. PATIENTS: One hundred consecutive subjects undergoing elective surgery for colorectal cancer....
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