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Article

Negative Regulation of the Antimetastatic Gene Nm23-H1 by Thyroid Hormone Receptors*

1 Jul 2000

Abstract excerpt

Metastasis of various malignant cells is inversely related to the abundance of the Nm23-H1 protein. The possible role of thyroid hormones in tumor metastasis has now been investigated by examining the effect of T3 on the expression of the Nm23-H1 gene. Human hepatoma HepG2 cells, in which endogenous thyroid hormone receptor subtype alpha1 (TRalpha1) is expressed at a low level, were stably transfected, either...

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Identifiers

PMID: 10875256
DOI: 10.1210/endo.141.7.7570

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