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Retroviruses, ascorbate, and mutations, in the evolution of Homo sapiens.

Free radical biology & medicine - 1 Jul 1998

Challem J J, Taylor E W

Abstract excerpt

Mutations, induced by free radicals, provide a rich molecular palette that other evolutionary forces can select for or against. A recent hypothesis proposed that large numbers of free radicals were produced when, millions of years ago, Anthropoidea lost the ability to produce endogenous ascorbate, increasing the frequency of mutations and accelerating the evolution of higher primates. Recognizing that...

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PMID: 9655531
DOI: 10.1016/s0891-5849(98)00034-3

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