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Article

The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease.

Medical hypotheses - 1 Jan 2008

Johnson Richard J, Gaucher Eric A, Sautin Yuri Y, Henderson George N, Angerhofer Alex J, Benner Steven A

Abstract excerpt

Humans have relatively low plasma ascorbate levels and high serum uric acid levels compared to most mammals due to the presence of genetic mutations in l-gulonolactone oxidase and uricase, respectively. We review the major hypotheses for why these mutations may have occurred. In particular, we suggest that both mutations may have provided a survival advantage to early primates by helping maintain blood pressure...

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Identifiers

PMID: 18331782
DOI: 10.1016/j.mehy.2008.01.017
PMCID: PMC2495042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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