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Article

Inactivation dates of the human and guinea pig vitamin C genes.

Genetica - 1 Feb 2011

Lachapelle Marc Y, Drouin Guy

Abstract excerpt

The capacity to biosynthesize ascorbic acid has been lost in a number of species including primates, guinea pigs, teleost fishes, bats, and birds. This inability results from mutations in the GLO gene coding for L-gulono-γ-lactone oxidase, the enzyme responsible for catalyzing the last step in the vitamin C biosynthetic pathway. We analyzed available primate and rodent GLO gene sequences to determine their...

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PMID: 21140195
DOI: 10.1007/s10709-010-9537-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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