Article
Alternative dystrophin gene transcripts in golden retriever muscular dystrophy.
Muscle & nerve - 1 Aug 1998
Schatzberg S J, Anderson L V, Wilton S D, Kornegay J N, Mann C J, Solomon G G, Sharp N J
Abstract excerpt
Golden retriever muscular dystrophy (GRMD), the canine model of Duchenne muscular dystrophy (DMD), is caused by a splice site mutation in the dystrophin gene. This mutation predicts a premature termination codon in exon 8 and a peptide that is 5% the size of normal dystrophin. Western blot analysis of skeletal muscle from GRMD dogs reveals a slightly truncated 390-kD protein that is approximately 91% the size of...
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