Article
Alternative dystrophin gene transcripts in golden retriever muscular dystrophy.
Muscle & nerve - 1 Aug 1998
Schatzberg S J, Anderson L V, Wilton S D, Kornegay J N, Mann C J, Solomon G G, Sharp N J
Abstract excerpt
Golden retriever muscular dystrophy (GRMD), the canine model of Duchenne muscular dystrophy (DMD), is caused by a splice site mutation in the dystrophin gene. This mutation predicts a premature termination codon in exon 8 and a peptide that is 5% the size of normal dystrophin. Western blot analys...
Topics
- Alternative Splicing
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Blotting, Western
- DNA Mutational Analysis
- Disease Models, Animal
- Dogs
- Dystrophin
- Exons
- Molecular Sequence Data
- Muscle, Skeletal
- Muscular Dystrophies
- Muscular Dystrophy, Animal
- Phenotype
- Polymerase Chain Reaction
- Transcription, Genetic