Article
An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy.
Genomics - 1 May 1992
Sharp N J, Kornegay J N, Van Camp S D, Herbstreith M H, Secore S L, Kettle S, Hung W Y, Constantinou C D, Dykstra M J, Roses A D
Abstract excerpt
Golden retriever muscular dystrophy (GRMD) is a spontaneous, X-linked, progressively fatal disease of dogs and is also a homologue of Duchenne muscular dystrophy (DMD). Two-thirds of DMD patients carry detectable deletions in their dystrophin gene. The defect underlying the remaining one-third of DMD patients is undetermined. Analysis of the canine dystrophin gene in normal and GRMD dogs has failed to demonstrate...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Dogs
- Dystrophin
- Exons
- Introns
- Male
- Molecular Sequence Data