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Article

Epidermal growth factor induction of human papillomavirus type 16 E6/E7 MRNA in tumor cells involves two AP-1 binding sites in the viral enhancer.

The Journal of general virology - 1 Aug 1995

Peto M, Tolle-Ersü I, Kreysch H G, Klock G

Abstract excerpt

The early genes E6 and E7 from human papillomaviruses (HPVs) play a key role in the development of cervical cancer. Modulation of E6 and E7 gene expression may alter tumour progression; therefore, modifiers of viral transcription such as hormones or growth factors are potential risk factors in cancer development. We have analysed the effects of epidermal growth factor (EGF) on E6/E7 mRNA from human papillomavirus...

Topics

Base Sequence
Cell Line, Transformed
DNA, Neoplasm
Disease Progression
Enhancer Elements, Genetic
Epidermal Growth Factor
Female
Gene Expression Regulation, Viral
Humans
Keratinocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oncogene Proteins, Viral

Papillomaviridae

Papillomavirus E7 Proteins

RNA, Messenger

RNA, Viral

Repressor Proteins

Source

Identifiers

PMID: 7636475
DOI: 10.1099/0022-1317-76-8-1945

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7636475-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Epidermal growth factor induction of human papillomavirus type 16 E6/E7 MRNA in tumor cells involves two AP-1 binding sites in the viral enhancer.PMID 7636475Read ↗

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