Article
Ras modifies proliferation and invasiveness of cells expressing human papillomavirus oncoproteins.
Journal of virology - 1 Sept 2008
Yoshida Satoshi, Kajitani Naoko, Satsuka Ayano, Nakamura Hiroyasu, Sakai Hiroyuki
Abstract excerpt
Infection by human papillomavirus (HPV) is a major risk factor for human cervical carcinoma. However, the HPV infection alone is not sufficient for cancer formation. Cervical carcinogenesis is considered a multistep process accompanied by genetic alterations of the cell. Ras is activated in approximately 20% of human cancers, and it is related to the metastatic conversion of tumor cells. We investigated how Ras...
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