Toxoplasma gondii: characterization of a mutant resistant to sulfonamides.

doi:10.1016/0014-4894(92)90149-5

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Article

Toxoplasma gondii: characterization of a mutant resistant to sulfonamides.

Experimental parasitology - 1 May 1992

Pfefferkorn E R, Borotz S E, Nothnagel R F

Abstract excerpt

Sulfadiazine was a potent inhibitor of the in vitro growth of Toxoplasma gondii, although it had little effect during the first 24 hr of treatment. A mutant parasite (R-SulR-5) with a 300-fold increase in sulfadiazine resistance was selected by a combination of chemical mutagenesis and growth in...

Topics

4-Aminobenzoic Acid
Animals
Dihydropteroate Synthase
Drug Resistance
Mutation
Sulfadiazine
Sulfonamides
Toxoplasma

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