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Article

Algorithmic approach to high-throughput molecular screening for alpha interferon-resistant genotypes in hepatitis C patients.

Journal of clinical microbiology - 1 Jul 1998

Sreevatsan S, Bookout J B, Ringpis F M, Pottathil M R, Marshall D J, De Arruda M, Murvine C, Fors L, Pottathil R M, Barathur R R

Abstract excerpt

This study was designed to analyze the feasibility and validity of using Cleavase Fragment Length Polymorphism (CFLP) analysis as an alternative to DNA sequencing for high-throughput screening of hepatitis C virus (HCV) genotypes in a high-volume molecular pathology laboratory setting. By using a...

Topics

Algorithms
Costs and Cost Analysis
DNA Fingerprinting
Drug Resistance, Microbial
Endonucleases
Genetic Techniques
Genotype
Hepacivirus
Hepatitis C
Humans
Interferon-alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Sensitivity and Specificity

Sequence Analysis, DNA

Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 9650932
DOI: 10.1128/JCM.36.7.1895-1901.1998
PMCID: PMC104948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9650932-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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