Exploiting tumour hypoxia and overcoming mutant p53 with tirapazamine.

doi:10.1038/bjc.1998.430

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Article

Exploiting tumour hypoxia and overcoming mutant p53 with tirapazamine.

British journal of cancer - 1 Jun 1998

Brown J M

Abstract excerpt

Human solid tumours are composed of a significant proportion of hypoxic cells, i.e. cells with oxygen levels lower than those of normal tissues. Tumour hypoxic cells have been shown to have a negative impact on the response of solid tumours to radiation therapy and chemotherapy. However, these lo...

Topics

Antineoplastic Agents
Cell Hypoxia
Cisplatin
Genes, p53
Humans
Mutation
Neoplasms
Tirapazamine
Triazines

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