Article

Systemic CYP3A inhibition by ritonavir enables selective targeting of hypoxic tumour cells by prodrugs of DNA-PK inhibitors

2026-02-14

Abstract excerpt

Hypoxic tumour cells are resistant to many forms of cancer therapy, particularly radiotherapy. Hypoxia-activated prodrugs (HAPs) can potentially address this problem through selective release of drugs (‘effectors’) in oxygen-deficient microenvironments, via metabolic reduction of a nitro(hetero)aromatic ‘trigger’ moiety. While many such HAPs show marked selectivity for hypoxia in cell culture, none have yet been a...

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Literature Corpus work: edc78cde-b891-57f9-89b5-e6cde462270e
DOI: 10.64898/2026.02.12.705643

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