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Article

Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells.

Cancer research - 1 Jan 2008

Evans James W, Chernikova Sophia B, Kachnic Lisa A, Banath Judit P, Sordet Olivier, Delahoussaye Yvette M, Treszezamsky Alejandro, Chon Brian H, Feng Zhihui, Gu Yongchuan, Wilson William R, Pommier Yves, Olive Peggy L, Powell Simon N, Brown J Martin

Abstract excerpt

Tirapazamine (3-amino-1,2,4-benzotriazine-1,4-dioxide) is a promising hypoxia-selective cytotoxin that has shown significant activity in advanced clinical trials in combination with radiotherapy and cisplatin. The current study aimed to advance our understanding of tirapazamine-induced lesions an...

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Source

Identifiers

PMID: 18172318
DOI: 10.1158/0008-5472.CAN-06-4497

Genes

ERCC1
BRCA1
BRCA2
XRCC2
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18172318-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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