Article
Tirapazamine: prototype for a novel class of therapeutic agents targeting tumor hypoxia.
Seminars in oncology - 1 Feb 2002
Gandara David R, Lara Primo N, Goldberg Zelanna, Le Quynh T, Mack Phillip C, Lau Derick H M, Gumerlock Paul H
Abstract excerpt
Preclinical models in vitro and in vivo have shown that tumor hypoxia alters the malignant cell phenotype, selecting for p53 mutations, stimulating angiogenesis and metastasis, and markedly reducing the efficacy of both radiotherapy and chemotherapy. Similarly, clinical studies measuring pretreatment tumor oxygen status confirm that the presence of hypoxia confers a negative impact on local control, disease-free...
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