Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3).

doi:10.1016/s0006-3223(97)00343-0

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Article

Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3).

Biological psychiatry - 1 Jul 1998

Mynett-Johnson L, Murphy V, McCormack J, Shields D C, Claffey E, Manley P, McKeon P

Abstract excerpt

BACKGROUND: Disturbances in central nervous system Na+, K+ adenosine triphosphatase (ATPase) activity have previously been proposed as being involved in the pathophysiology of bipolar mood disorder. METHODS: We have examined one particular alpha subunit of this enzyme for allelic association in a...

Topics

Adult
Aged
Alleles
Bipolar Disorder
Brain
Case-Control Studies
Chi-Square Distribution
Dinucleotide Repeats
Female
Gene Expression
Genetic Markers
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ireland

Male

Middle Aged

Polymerase Chain Reaction

Polymorphism, Genetic

Sodium-Potassium-Exchanging ATPase

Source

Open in PubMed

Identifiers

PMID: 9646882
DOI: 10.1016/s0006-3223(97)00343-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9646882-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3).PMID 9646882Read ↗

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Decreased neuronal Na+, K+ -ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress.Semantic proximity Read ↗

An Exploratory Case-Control Study for Mitochondrial DNA G10398A in Bipolar I Disorder Patients with a Family History of Affective Disorders.Semantic proximity Read ↗

Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish.Semantic proximity Read ↗

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No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder.Semantic proximity Read ↗

The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study.Semantic proximity Read ↗

No evidence for allelic association between bipolar disorder and monoamine oxidase A gene polymorphisms.Semantic proximity Read ↗

No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder.Semantic proximity Read ↗

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