Article
Effect of targeted mutation in collagen V alpha 2 gene on development of cutaneous hyperplasia in tight skin mice.
Molecular medicine (Cambridge, Mass.) - 1 May 1998
Phelps R G, Murai C, Saito S, Hatakeyama A, Andrikopoulos K, Kasturi K N, Bona C A
Abstract excerpt
Collagen V plays a major regulatory role in the formation of heterotypic fibers of the dermis and cartilaginous tissues as well as in the assembly of extracellular matrix. The pN/pN mouse, which is defective in collagen V alpha 2 gene, exhibits skeletal abnormalities, skin fragility, and alterations in the collagen fiber organization, whereas the TSK/+ mouse, which is defective in fibrillin-1, the major component...
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