Effect of targeted mutation in collagen V alpha 2 gene on development of cutaneous hyperplasia in tight skin mice.

Article

Effect of targeted mutation in collagen V alpha 2 gene on development of cutaneous hyperplasia in tight skin mice.

Molecular medicine (Cambridge, Mass.) - 1 May 1998

Phelps R G, Murai C, Saito S, Hatakeyama A, Andrikopoulos K, Kasturi K N, Bona C A

Abstract excerpt

Collagen V plays a major regulatory role in the formation of heterotypic fibers of the dermis and cartilaginous tissues as well as in the assembly of extracellular matrix. The pN/pN mouse, which is defective in collagen V alpha 2 gene, exhibits skeletal abnormalities, skin fragility, and alterati...

Topics

Alleles
Animals
Autoantibodies
Collagen
DNA Topoisomerases, Type I
Hyperplasia
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mutagenesis, Site-Directed
Phenotype
Skin

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