Article
Tight-skin (Tsk) maps on mouse chromosome 2 within the region of linkage homology with human chromosome 15.
Genomics - 1 Jul 1994
Douté R C, Clark S H
Abstract excerpt
The tight-skin (Tsk) mutation has been mapped to mouse chromosome 2 between the visible markers pallid (pa) and agouti (a). The phenotype observed in Tsk heterozygotes includes a thickened dermis that is tightly adherent to underlying tissues, increased production of collagen and other matrix proteins in the dermis, an enlarged heart, overgrowth of bones, scoliosis, and emphysematous lungs. Although it is known...
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