Article
Induction of skin fibrosis in mice expressing a mutated fibrillin-1 gene.
Molecular medicine (Cambridge, Mass.) - 1 Oct 2000
Saito S, Nishimura H, Phelps R G, Wolf I, Suzuki M, Honjo T, Bona C
Abstract excerpt
BACKGROUND: Tight skin mice (TSK) bear a mutated Fibrillin-1 (Fbn-1) gene. Genetic studies show that the TSK mutation is closely associated with the Fbn-1 locus (0-0.7 cM). A previous study showed two recombinants between the Fbn-1 locus and the TSK mutation. TSK mutation and mutated Fbn-1 gene cosegregate in F1 mice. MATERIALS AND METHODS: To elucidate the role of the mutated Fbn-1 gene in occurrence of TSK...
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