Article
The tight skin (Tsk) mutation in the mouse, a model for human fibrotic diseases, is tightly linked to the beta 2-microglobulin (B2m) gene on chromosome 2.
Genomics - 1 Sept 1993
Siracusa L D, Christner P, McGrath R, Mowers S D, Nelson K K, Jimenez S A
Abstract excerpt
The Tsk mutation in the mouse is characterized by the excessive accumulation of collagen in skin and various internal organs, including the heart and lungs. These connective tissue abnormalities are similar to those present in human systemic sclerosis or scleroderma. The Tsk mutation provides an opportunity to investigate, at the molecular level, the pathogenesis of tissue fibrosis. As a first step to cloning the...
Topics
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Disease Models, Animal
- Female
- Genetic Linkage
- Genetic Markers
- Humans
- Male
- Mice
- Mice, Inbred C57BL