Group B streptococci (GBS) injure lung endothelium in vitro: GBS invasion and GBS-induced eicosanoid production is greater with microvascular than with pulmonary artery cells.

Abstract excerpt

Neonatal group B streptococcal (GBS) sepsis and pneumonia cause lung endothelial cell injury. GBS invasion of the lung endothelium may be a mechanism for injury and the release of vasoactive eicosanoids. Pulmonary artery endothelial cells (PAEC) and lung microvascular endothelial cells (LMvEC) we...

Topics

• Animals
• Animals, Newborn
• Bacterial Capsules
• Cells, Cultured
• Dinoprostone
• Eicosanoids
• Endothelium, Vascular
• Epoprostenol
• Lung
• Microcirculation
• Mutation
• Polysaccharides, Bacterial