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Article

Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c mice

1 Jun 1998

Abstract excerpt

OBJECTIVE: To analyze the structure, specificity, and in vivo pathogenetic potential of 2 human anticardiolipin (aCL) monoclonal antibodies (MAb). METHODS: Human aCL IgG MAb were generated from hybridized Epstein-Barr virus-induced B cell lines from a healthy subject (MAb 519) and from a patient with primary antiphospholipid syndrome (MAb 516). Studies of antigen-binding specificity and analysis of Ig V-gene...

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PMID: 9627012
DOI: 10.1002/1529-0131(199806)41:6<1026::aid-art9>3.0.co;2-1

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