Article
Heterogeneity and diversity of IgM and IgG lupus anticoagulants in an individual with systemic lupus erythematosus.
Biochemical and biophysical research communications - 30 Sept 1994
Nakamura N, Azuma C, Akamizu T, Sugawa H, Matsuda F, Mitsuda N, Honjo T, Mori T, Yamaji K
Abstract excerpt
From one patient with systemic lupus erythematosus retaining lupus anticoagulant (LAC), we established 6 Epstein-Barr virus-transformed human B cell clones secreting antibodies that affect the coagulation assay. Two and 4 of the clones secreted IgM and IgG antibodies, respectively. Although all 6...
Topics
- Adult
- Antibodies, Monoclonal
- B-Lymphocytes
- Blotting, Southern
- Cell Line, Transformed
- Clone Cells
- Enzyme-Linked Immunosorbent Assay
- Female
- Genetic Variation
- Herpesvirus 4, Human
- Humans
- Immunoglobulin G
- Immunoglobulin Isotypes
- Immunoglobulin M
- Lupus Coagulation Inhibitor