Article
Heterogeneity and diversity of IgM and IgG lupus anticoagulants in an individual with systemic lupus erythematosus.
Biochemical and biophysical research communications - 30 Sept 1994
Nakamura N, Azuma C, Akamizu T, Sugawa H, Matsuda F, Mitsuda N, Honjo T, Mori T, Yamaji K
Abstract excerpt
From one patient with systemic lupus erythematosus retaining lupus anticoagulant (LAC), we established 6 Epstein-Barr virus-transformed human B cell clones secreting antibodies that affect the coagulation assay. Two and 4 of the clones secreted IgM and IgG antibodies, respectively. Although all 6 antibodies displayed anticardiolipin activity in ELISA, the increased binding activity in the presence of beta...
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