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Article

Selective and Rapid Uptake of Adeno-Associated Virus Type 2 in Brain

20 May 1998

Abstract excerpt

Recombinant adeno-associated virus (AAV) vectors effectively transfer and express foreign genes in the brain. The transferred genes, however, are selectively expressed in neurons, and the cause of this specificity is not understood. To address this question, wild-type AAV-2 capsids were covalently labeled with the fluorophore, Cy3, and infused into the inferior colliculus or the hippocampus. Using antibodies to...

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Identifiers

PMID: 9625257
DOI: 10.1089/hum.1998.9.8-1181

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