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Article

Recombinant AAV-mediated gene delivery to the central nervous system

1 Feb 2004

Abstract excerpt

Various regions of the brain have been successfully transduced by recombinant adeno-associated virus (rAAV) vectors with no detected toxicity. When using the cytomegalovirus immediate early (CMV) promoter, a gradual decline in the number of transduced cells has been described. In contrast, the use of cellular promoters such as the neuron-specific enolase promoter or hybrid promoters such as the chicken...

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PMID: 14978764
DOI: 10.1002/jgm.506

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