Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo.

Science translational medicine - 18 Jul 2018

Richmond Jillian M, Strassner James P, Zapata Lucio, Garg Madhuri, Riding Rebecca L, Refat Maggi A, Fan Xueli, Azzolino Vincent, Tovar-Garza Andrea, Tsurushita Naoya, Pandya Amit G, Tso J Yun, Harris John E

Abstract excerpt

Vitiligo is an autoimmune disease of the skin mediated by CD8+ T cells that kill melanocytes and create white spots. Skin lesions in vitiligo frequently return after discontinuing conventional treatments, supporting the hypothesis that autoimmune memory is formed at these locations. We found that lesional T cells in mice and humans with vitiligo display a resident memory (TRM) phenotype, similar to those that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Blocking
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermis

Share to Immunologic Memory

Share to Interferon-gamma

Share to Interleukin-15

Share to Melanocytes

Share to Vitiligo

Source

Open in PubMed Open full text

Identifiers

PMID: 30021889
DOI: 10.1126/scitranslmed.aam7710
PMCID: PMC6495055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo.PMID 30021889Read ↗

Vitiligo: Mechanisms of Pathogenesis and TreatmentSemantic proximity Read ↗

Tissue-resident memory T cells in the skin.Semantic proximity Read ↗

The Pathogenic Role of CD4+ Tissue-Resident Memory T Cells Bearing T Follicular Helper-Like Phenotype in Pemphigus Lesions.Semantic proximity Read ↗

Inflammatory Memory in Chronic Skin DiseaseSemantic proximity Read ↗

Cutting Edge: Identification of a Motile IL-17–Producing γδ T Cell Population in the DermisSemantic proximity Read ↗

TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15.Semantic proximity Read ↗

The interleukin-15 system suppresses T cell-mediated autoimmunity by regulating negative selection and nT(H)17 cell homeostasis in the thymus.Semantic proximity Read ↗

Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strainSemantic proximity Read ↗

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.Semantic proximity Read ↗

Jak Inhibitors Reverse Vitiligo in Mice but Do Not Deplete Skin Resident Memory T CellsSemantic proximity Read ↗

Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytesSemantic proximity Read ↗

IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.