Article
Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium.
Journal of the neurological sciences - 15 Aug 2011
McGuire V, Van Den Eeden S K, Tanner C M, Kamel F, Umbach D M, Marder K, Mayeux R, Ritz B, Ross G W, Petrovitch H, Topol B, Popat R A, Costello S, Manthripragada A D, Southwick A, Myers R M, Nelson L M
Abstract excerpt
OBJECTIVE: To examine genetic associations of polymorphisms in the dopamine receptor D2 (DRD2) and D3 (DRD3) genes with risk of Parkinson's disease (PD). METHODS: The study included 1325 newly diagnosed patients with PD and 1735 controls from a consortium of five North American case-control studies. We collected risk factor information by in-person or telephone interview. Six DRD2 and two DRD3 polymorphisms were...
Topics
- Black or African American
- Aged
- Case-Control Studies
- Female
- Genetic Carrier Screening
- Genetic Predisposition to Disease
- Genotype
- Hispanic or Latino
- Humans
- Male