Article
Genetic susceptibility to Parkinson's disease among South and North Indians: I. Role of polymorphisms in dopamine receptor and transporter genes and association of DRD4 120-bp duplication marker.
Neurogenetics - 1 Nov 2006
Juyal Ramesh C, Das Mitashree, Punia Sohan, Behari Madhuri, Nainwal Geetika, Singh Sumit, Swaminath Pazhayannur V, Govindappa Shyla T, Jayaram Sachi, Muthane Uday B, Thelma B K
Abstract excerpt
The depletion of dopamine levels in the brain due to degeneration of dopaminergic neurons of substantia nigra pars compacta is a hallmark of Parkinson's disease (PD). The cumulative contribution of genetic variations in genes from the dopaminergic pathway has been widely implicated to confer susceptibility to idiopathic PD. We present in this paper an extensive association analysis of a total of 20 markers...
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