Article
Clinical manifestations due to a point mutation of the mitochondrial tRNAleu(UUR) gene in five families with diabetes mellitus.
Internal medicine (Tokyo, Japan) - 1 Mar 1998
Shigemoto M, Yoshimasa Y, Yamamoto Y, Hayashi T, Suga J, Inoue G, Okamoto M, Jingami H, Tsuda K, Yamamoto T, Yagura T, Oishi M, Tsujii S, Kuzuya H, Nakao K
Abstract excerpt
It has been shown that an adenine (A) to guanine (G) transition at position 3243 of the mitochondrial transfer RNA(tRNA)leu(UUR) gene is associated with a subgroup of diabetes mellitus. Therefore, we screened for this transition in 86 patients with non-insulin-dependent diabetes mellitus (NIDDM)...
Topics
- Adolescent
- Adult
- Aged
- Blood Glucose
- DNA Primers
- DNA, Mitochondrial
- Diabetes Complications
- Diabetes Mellitus
- Female
- Genotype
- Glucose Clamp Technique
- Humans
- Hypoparathyroidism
- Insulin