Article
Retinol-induced secretion of human retinol-binding protein in yeast.
FEBS letters - 8 May 1998
Reppe S, Smeland S, Moskaug J O, Blomhoff R
Abstract excerpt
Retinol-binding protein (RBP) functions as a transporter for retinol (vitamin A) in plasma in higher eukaryotes. We have successfully expressed human RBP in Saccharomyces cerevisiae, and its secretion was found to be induced by retinol also in this lower eukaryote. Reduced induction of secretion by retinol in a temperature-sensitive sec18-1 mutant that is blocked in secretion at the restricted temperature...
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