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Article

Use of parthenogenetic activation of human oocytes as an experimental model for evaluation of polar body based PGD assay performance.

Journal of assisted reproduction and genetics - 1 May 2011

Paffoni Alessio, Paracchini Valentina, Ferrari Stefania, Scarduelli Claudia, Seia Manuela, Coviello Domenico A, Ragni Guido

Abstract excerpt

PURPOSE: To develop an experimental model to assess the feasibility of polar body preimplantation genetic diagnosis without requiring oocyte fertilization. METHODS: First polar body was removed from donated oocytes and second polar body was biopsied after parthenogenetic activation. Molecular analysis on both polar bodies involved a fluorescent multiplex polymerase chain reaction of short-tandem repeat markers,...

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Identifiers

PMID: 21360136
DOI: 10.1007/s10815-011-9540-x
PMCID: PMC3151362

Genes

CFTR
HBB
PGD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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