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Article

Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome.

Human genetics - 1 Apr 1998

Itoh T, Tanaka T, Nagai R, Kamiya T, Sawayama T, Nakayama T, Tomoike H, Sakurada H, Yazaki Y, Nakamura Y

Abstract excerpt

Familial long QT syndrome (LQTS) is characterized by prolonged ventricular repolarization. Clinical symptoms include recurrent syncopal attacks, and sudden death may occur as a result of ventricular tachyarrhythmias. Three genes responsible for this syndrome (KVLQT1, HERG, and SCN5A) have been identified so far, and mutations have been reported on the basis of partially characterized genomic organization. To...

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PMID: 9600240
DOI: 10.1007/s004390050717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome.PMID 9600240Read ↗

Four novel KVLQT1 and four novel HERG mutations in familial long-QT syndrome.Semantic proximity Read ↗

Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1.Semantic proximity Read ↗

Missense mutation in the pore region of HERG causes familial long QT syndrome.Semantic proximity Read ↗

Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome.Semantic proximity Read ↗

Survey of the coding region of the HERG gene in long QT syndrome reveals six novel mutations and an amino acid polymorphism with possible phenotypic effects.Semantic proximity Read ↗

Romano-Ward long QT syndrome: identification of a HERG mutation in a Taiwanese kindred.Semantic proximity Read ↗

A novel splice mutation of HERG in a Chinese family with long QT syndrome.Semantic proximity Read ↗

C-terminal <i>HERG</i> MutationsSemantic proximity Read ↗

Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome.Semantic proximity Read ↗

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.Semantic proximity Read ↗

Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel.Semantic proximity Read ↗

Single nucleotide polymorphism map of five long-QT genes.Semantic proximity Read ↗

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