Article
Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome.
Human genetics - 1 Apr 1998
Itoh T, Tanaka T, Nagai R, Kamiya T, Sawayama T, Nakayama T, Tomoike H, Sakurada H, Yazaki Y, Nakamura Y
Abstract excerpt
Familial long QT syndrome (LQTS) is characterized by prolonged ventricular repolarization. Clinical symptoms include recurrent syncopal attacks, and sudden death may occur as a result of ventricular tachyarrhythmias. Three genes responsible for this syndrome (KVLQT1, HERG, and SCN5A) have been id...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Cation Transport Proteins
- DNA Mutational Analysis
- DNA-Binding Proteins
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels
- Exons
- Humans
- Introns
- Long QT Syndrome
- Molecular Sequence Data
- Mutation
- Pedigree
- Potassium Channels