Article
Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome.
Pediatric research - 1 May 2003
Johnson Walter H, Yang Ping, Yang Tao, Lau Yung R, Mostella Barbara A, Wolff Daynna J, Roden Dan M, Benson D Woodrow
Abstract excerpt
Previous studies have identified mutations in five ion channel genes as a cause of long QT syndrome, a heterogeneous disorder characterized by prolongation of the QT interval, multiform ventricular tachycardia (torsades de pointes), seizures, syncope, and sudden death. However, in these studies, the average age of initial symptoms is in the third decade of life or later, and few reports have described the genetic...
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