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Article

C-terminal <i>HERG</i> Mutations

23 Mar 1999

Abstract excerpt

BACKGROUND: The long-QT syndrome (LQTS) is a genetically heterogeneous disease in which 4 genes encoding ion-channel subunits have been identified. Most of the mutations have been determined in the transmembrane domains of the cardiac potassium channel genes KCNQ1 and HERG. In this study, we investigated the 3' part of HERG for mutations. METHODS AND RESULTS: New specific primers allowed the amplification of the...

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Identifiers

PMID: 10086971
DOI: 10.1161/01.cir.99.11.1464

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C-terminal <i>HERG</i> MutationsPMID 10086971Read ↗

Missense mutation in the pore region of HERG causes familial long QT syndrome.Semantic proximity Read ↗

Homozygosity for a HERG potassium channel mutation causes a severe form of long QT syndrome: identification of an apparent founder mutation in the Finns.Semantic proximity Read ↗

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndromeSemantic proximity Read ↗

Survey of the coding region of the HERG gene in long QT syndrome reveals six novel mutations and an amino acid polymorphism with possible phenotypic effects.Semantic proximity Read ↗

A novel splice mutation of HERG in a Chinese family with long QT syndrome.Semantic proximity Read ↗

Homozygous premature truncation of the HERG protein : the human HERG knockout.Semantic proximity Read ↗

Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome.Semantic proximity Read ↗

Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1.Semantic proximity Read ↗

A mutation in HERG associated with notched T waves in long QT syndrome.Semantic proximity Read ↗

Romano-Ward long QT syndrome: identification of a HERG mutation in a Taiwanese kindred.Semantic proximity Read ↗

Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome.Semantic proximity Read ↗

A missense mutation (G604S) in the S5/pore region of HERG causes long QT syndrome in a Chinese family with a high incidence of sudden unexpected death.Semantic proximity Read ↗

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