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Article

Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatment.

The Journal of infectious diseases - 15 Dec 2002

Curtis J, Maxwell C A, Msuya F H M, Mkongewa S, Alloueche A, Warhurst D C

Abstract excerpt

Treatment with the novel antifolate drug combination chlorproguanil-dapsone effectively cleared asymptomatic Plasmodium falciparum infections in 246 (93.5%) of 263 children in the Usambara Mountains of Tanzania during the course of a 2-week follow-up. Samples from 71 recurrent infections, collected over a 9-week follow-up, showed selection for parasites with the triple mutant Ile(51)-Arg(59)-Asn(108) in...

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PMID: 12447777
DOI: 10.1086/345765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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