Article
Genotypic analysis of cytomegalovirus retinitis poorly responsive to intravenous ganciclovir but responsive to the ganciclovir implant.
American journal of ophthalmology - 1 Jan 2003
Kuo Irene C, Imai Yumi, Shum Carol, Martin Daniel F, Kuppermann Baruch D, Margolis Todd P
Abstract excerpt
PURPOSE: To determine whether cytomegalovirus (CMV) retinitis that responded poorly to intravenous ganciclovir therapy but responded to the ganciclovir implant was caused by virus with resistance mutations in the viral UL97 and UL54 genes. DESIGN: Retrospective chart review and laboratory-based experimental study. METHODS: Regions of the CMV UL97 and UL54 were amplified from the vitreous and analyzed for...
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