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Article

Prospect of rindopepimut in the treatment of glioblastoma

5 Mar 2017

Abstract excerpt

INTRODUCTION: Rindopepimut (CDX-110) is a peptide vaccine that targets epidermal growth factor receptor variant III (EGFRvIII), a tumor-specific epitope expressed in the most common and lethal primary malignant neoplasm of the brain - glioblastoma (GBM). Areas covered: The EGFRvIII mutation introduces an 801 base pair in-frame deletion of the extracellular domain of the transmembrane tyrosine kinase, resulting in...

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PMID: 28274144
DOI: 10.1080/14712598.2017.1299705

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