Article
Effect of Phlebotomus papatasi on the fitness, infectivity and antimony-resistance phenotype of antimony-resistant Leishmania major Mon-25.
International journal for parasitology. Drugs and drug resistance - 1 Aug 2024
Mekarnia Nalia, Benallal Kamal-Eddine, Sádlová Jovana, Vojtková Barbora, Mauras Aurélie, Imbert Nicolas, Longhitano Maryline, Harrat Zoubir, Volf Petr, Loiseau Philippe M, Cojean Sandrine
Abstract excerpt
Leishmania major is responsible for zoonotic cutaneous leishmaniasis. Therapy is mainly based on the use of antimony-based drugs; however, treatment failures and illness relapses were reported. Although studies were developed to understand mechanisms of drug resistance, the interactions of resistant parasites with their reservoir hosts and vectors remain poorly understood. Here we compared the development of two...
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