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Article

Unveiling ancestral threads: Exploring CCR5 ∆32 mutation frequencies in Colombian populations for HIV/AIDS therapeutics.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2024

Barrios-Navas Alejandro, Nguyen Thanh Long, Gallo Juan Esteban, Mariño-Ramírez Leonardo, Soto José María Satizabal, Sánchez Adalberto, Jordan I King, Valderrama-Aguirre Augusto

Abstract excerpt

AIDS remains a significant global health challenge since its emergence in 1981, with millions of deaths and new cases every year. The CCR5 ∆32 genetic deletion confers immunity to HIV infection by altering a cell membrane protein crucial for viral entry. Stem cell transplants from homozygous carriers of this mutation to HIV-infected individuals have resulted in viral load reduction and disease remission,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39374819
DOI: 10.1016/j.meegid.2024.105680
PMCID: PMC11563905

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