Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans.

doi:10.1242/dev.125.12.2337

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Article

Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans.

Development (Cambridge, England) - 1 Jun 1998

Jiang L I, Sternberg P W

Abstract excerpt

We investigate how temporal and spatial interactions between multiple intercellular and intracellular factors specify the fate of a single cell in Caenorhabditis elegans. P12, which is a ventral cord neuroectoblast, divides postembryonically to generate neurons and a unique epidermal cell. Three classes of proteins are involved in the specification of P12 fate: the LIN-3/LET-23 epidermal growth factor signaling...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Differentiation
Cell Lineage
Epidermal Cells
Epidermal Growth Factor
ErbB Receptors
Genes, Helminth
Genes, Homeobox
Glycoproteins
Helminth Proteins
Homeodomain Proteins
Mutation
Neurons
Receptors, Cell Surface
Receptors, G-Protein-Coupled
Signal Transduction

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Open in PubMed

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PMID: 9584132
DOI: 10.1242/dev.125.12.2337

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