Article
CD69, an early activation antigen on lymphocytes, is constitutively expressed by human epidermal Langerhans cells.
The Journal of investigative dermatology - 1 May 1992
Bieber T, Rieger A, Stingl G, Sander E, Wanek P, Strobel I
Abstract excerpt
When screening skin cryosections with a panel of monoclonal antibodies (MoAb), we found that the anti-CD69 MoAb Leu-23 reacted with a subpopulation of epidermal dendritic cells, presumably Langerhans cells (LC). The staining intensity was enhanced by gentle trypsin pretreatment of the sections. Flow cytometric analysis of LC-enriched epidermal cells (EC) revealed that nearly all CD1a-bearing LC display anti-CD69...
Topics
- Antibodies, Monoclonal
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Cells, Cultured
- Humans
- Interferon-gamma
- Langerhans Cells
- Lectins, C-Type
- Membrane Proteins
- Molecular Structure