Article
Tissue factor expression by endothelial cells in sickle cell anemia.
The Journal of clinical investigation - 1 May 1998
Solovey A, Gui L, Key N S, Hebbel R P
Abstract excerpt
The role of the vascular endothelium in activation of the coagulation system, a fundamental homeostatic mechanism of mammalian biology, is uncertain because there is little evidence indicating that endothelial cells in vivo express tissue factor (TF), the system's triggering mechanism. As a surrogate for vessel wall endothelium, we examined circulating endothelial cells (CEC) from normals and patients with sickle...
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