Article
Circulating activated endothelial cells in sickle cell anemia.
The New England journal of medicine - 27 Nov 1997
Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel R P
Abstract excerpt
BACKGROUND: The vascular wall participates in the pathogenesis of sickle cell disease. To determine whether the endothelium is activated in this disease, we studied the number, origin, and surface phenotype of circulating endothelial cells in patients with sickle cell anemia. METHODS: We used immunohistochemical examination of buffy-coat smears to enumerate circulating endothelial cells, and we evaluated the...
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