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Article

Chaos, persistence, and evolution of strain structure in antigenically diverse infectious agents.

Science (New York, N.Y.) - 8 May 1998

Gupta S, Ferguson N, Anderson R

Abstract excerpt

The effects of selection by host immune responses on transmission dynamics was analyzed in a broad class of antigenically diverse pathogens. Strong selection can cause pathogen populations to stably segregate into discrete strains with nonoverlapping antigenic repertoires. However, over a wide range of intermediate levels of selection, strain structure is unstable, varying in a manner that is either cyclical or...

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Identifiers

PMID: 9572737
DOI: 10.1126/science.280.5365.912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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