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Article

Antigenic diversity, transmission mechanisms, and the evolution of pathogens.

PLoS computational biology - 1 Oct 2009

Lange Alexander, Ferguson Neil M

Abstract excerpt

Pathogens have evolved diverse strategies to maximize their transmission fitness. Here we investigate these strategies for directly transmitted pathogens using mathematical models of disease pathogenesis and transmission, modeling fitness as a function of within- and between-host pathogen dynamics. The within-host model includes realistic constraints on pathogen replication via resource depletion and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19847288
DOI: 10.1371/journal.pcbi.1000536
PMCID: PMC2759524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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