Article
Mitochondrial DNA deletions in muscle satellite cells: implications for therapies.
Human molecular genetics - 1 Dec 2013
Spendiff Sally, Reza Mojgan, Murphy Julie L, Gorman Grainne, Blakely Emma L, Taylor Robert W, Horvath Rita, Campbell Georgia, Newman Jane, Lochmüller Hanns, Turnbull Doug M
Abstract excerpt
Progressive myopathy is a major clinical feature of patients with mitochondrial DNA (mtDNA) disease. There is limited treatment available for these patients although exercise and other approaches to activate muscle stem cells (satellite cells) have been proposed. The majority of mtDNA defects are heteroplasmic (a mixture of mutated and wild-type mtDNA present within the muscle) with high levels of mutated mtDNA...
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