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Article

Preferential amplification and phenotypic selection in a population of deleted and wild-type mitochondrial DNA in cultured cells.

Current genetics - 1 Aug 1997

Spelbrink J N, Zwart R, Van Galen M J, Van den Bogert C

Abstract excerpt

In order to study the still poorly understood dynamics of mitochondrial gene segregation, we attempted to alter the percentage of deleted mtDNA (del-mtDNA) over wild-type mtDNA in cell-culture by manipulating respiratory chain capacity. For this purpose, we used a cell-line harbouring a 6-kb mtDNA-deletion which normally was present in 70% of the molecules. The results show that in the presence of low...

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Share to Cell Division
Share to Cells, Cultured
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9294259
DOI: 10.1007/s002940050255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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