Article
Random mitotic segregation of mitochondrial DNA in MELAS syndrome.
Acta neurologica Scandinavica - 1 Jan 2000
Huang C C, Chen R S, Chu N S, Pang C Y, Wei Y H
Abstract excerpt
We describe the heterogeneity of clinical features and molecular genetic characteristics of the probands and other members in two families with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome. A point mutation at the 3243rd nucleotide position of...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- DNA Replication
- DNA, Mitochondrial
- Female
- Humans
- MELAS Syndrome
- Male
- Middle Aged
- Mitosis
- Molecular Biology
- Phenotype
- Polymorphism, Restriction Fragment Length