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Article

Phosphorylation and cytotoxicity of therapeutic nucleoside analogues: a comparison of alpha and gamma herpesvirus thymidine kinase suicide genes.

Cancer gene therapy - 1 Jan 2000

Cazaux C, Tiraby M, Loubiere L, Haren L, Klatzmann D, Tiraby G

Abstract excerpt

Thymidine kinase (TK) genes from three alpha-herpesviruses (i.e., human herpes simplex type 1, varicella-zoster virus, equid herpesvirus 4) and two y-herpesviruses (i.e., Epstein-Barr virus and Saimiri herpesvirus 2) were cloned in expression vectors based on zeocin resistance by complementation...

Topics

Animals
Antiviral Agents
Cell Line
Cell Survival
Cloning, Molecular
Didanosine
Escherichia coli
Floxuridine
Genetic Vectors
Herpesviridae
Mutation
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Stavudine

Thymidine Kinase

Tumor Cells, Cultured

Zidovudine

Source

Identifiers

PMID: 9570299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9570299-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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