Article
A Theileria annulata DNA binding protein localized to the host cell nucleus alters the phenotype of a bovine macrophage cell line.
Eukaryotic cell - 1 Apr 2004
Shiels Brian R, McKellar Sue, Katzer Frank, Lyons Kim, Kinnaird Jane, Ward Chris, Wastling Jonathan M, Swan David
Abstract excerpt
The apicomplexan parasite Theileria annulata is the only intracellular eukaryote that is known to induce the proliferation of mammalian cells. However, as the parasite undergoes stage differentiation, host cell proliferation is inhibited, and the leukocyte is eventually destroyed. We have isolated a parasite gene (SuAT1) encoding an AT hook DNA binding polypeptide that has a predicted signal peptide, PEST motifs,...
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